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KMID : 1123920060200051295
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Korean Journal of Oriental Physiology and Pathology
2006 Volume.20 No. 5 p.1295 ~ p.1302
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Inhibitory Effect of Panax notoginseng on Nitric Oxide Synthase, Cyclo-oxygenase-2 and Neutrophil Functions
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Park Soon-Gi
Joo Shin-Tak
Ban Chang-Gyu
Moon Jin-Young
Park Sun-Dong
Park Won-Hwan
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Abstract
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Our preliminary aim is to elucidate the pharmacokinetic features of the PNS(Panax notoginseng Buck F.H. Chen. (Arialiaceae) root). First, we assessed the prevention of neurtrophil functions. A Panax notoginseng inhibited neutrophil functions, including degranulation, superoxide generation, and leukotriene B4 production, without any effect on 5-lipoxygenase activity. This Panax notoginseng reduced nitric oxide (NO) and prostaglandin E2 production in mouse peritoneal macrophages stimulated with lipopolysaccharide, whereas no influence on the activity of inducible NO synthase, cyclo-oxygenase-2 or cyclo-oxygenase-1 was observed. Panax notoginseng significantly reduced mouse paw oedema induced by carrageenan. The results indicate that Panax notoginseng exerts anti-inflammatory effects related to the inhibition of neutrophil functions and of NO and prostaglandin E2 production, which could be due to a decreased expression of inducible NO synthase and cyclo-oxygenase-2.
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KEYWORD
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PNS(Panax notoginseng), neurtrophil functions, nitric oxide (NO), prostaglandin E2, cyclo-oxygenase-2
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